leiomyosarcoma ulms cell line Search Results


leiomyosarcoma ulms cell line  (ATCC)
95
ATCC leiomyosarcoma ulms cell line
Figure 1. Morphological observation and IHC staining of SMA, desmin, and HMB45 in four repre- sentative human <t>uLMS</t> tissues and adjacent myometrium.
Leiomyosarcoma Ulms Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Figure 1. Morphological observation and IHC staining of SMA, desmin, and HMB45 in four repre- sentative human uLMS tissues and adjacent myometrium.

Journal: Cells

Article Title: The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma.

doi: 10.3390/cells11142160

Figure Lengend Snippet: Figure 1. Morphological observation and IHC staining of SMA, desmin, and HMB45 in four repre- sentative human uLMS tissues and adjacent myometrium.

Article Snippet: The leiomyosarcoma (uLMS) cell line (SK-UT1, ATCC® HTB-114TM) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

Techniques: Immunohistochemistry

Figure 4. BRD9 inhibition causes extensive changes in the transcriptome of uLMS cells. (A) Pie chart showing the percentage of genes that exhibited changes in RNA expression between TP-472 and vehicle treatment groups as determined by RNA-seq. The cutoff value is 1.5-fold with an FDA < 0.05. (B) PCA plot of BRD9/inhibitor (TP-472) and vehicle control (DMSO), (C): Volcano plot showing the distribution of the DEGs between TP-472 and vehicle-treated SK-UT-1 cell line. The dashed line indicates the p-value significance threshold. (D) Heat map. Pearson correlation was used to cluster DEG (TP-472 vs. Control), which were then represented as a heatmap with the data scaled by Z score for each row. (E) Heat map. Pearson correlation was used to cluster DEG (TP-472 vs. Control, up genes), which were then represented as a heatmap with the data scaled by Z score for each row. (F) Heat map. Pearson correlation was used to cluster DEG (TP-472 vs. Control, down genes), which were then represented as a heatmap with the data scaled by Z score for each row.

Journal: Cells

Article Title: The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma.

doi: 10.3390/cells11142160

Figure Lengend Snippet: Figure 4. BRD9 inhibition causes extensive changes in the transcriptome of uLMS cells. (A) Pie chart showing the percentage of genes that exhibited changes in RNA expression between TP-472 and vehicle treatment groups as determined by RNA-seq. The cutoff value is 1.5-fold with an FDA < 0.05. (B) PCA plot of BRD9/inhibitor (TP-472) and vehicle control (DMSO), (C): Volcano plot showing the distribution of the DEGs between TP-472 and vehicle-treated SK-UT-1 cell line. The dashed line indicates the p-value significance threshold. (D) Heat map. Pearson correlation was used to cluster DEG (TP-472 vs. Control), which were then represented as a heatmap with the data scaled by Z score for each row. (E) Heat map. Pearson correlation was used to cluster DEG (TP-472 vs. Control, up genes), which were then represented as a heatmap with the data scaled by Z score for each row. (F) Heat map. Pearson correlation was used to cluster DEG (TP-472 vs. Control, down genes), which were then represented as a heatmap with the data scaled by Z score for each row.

Article Snippet: The leiomyosarcoma (uLMS) cell line (SK-UT1, ATCC® HTB-114TM) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

Techniques: Inhibition, RNA Expression, RNA Sequencing, Control

Figure 9. Visualization of the top 200 DEGs involved in miRNA regulation. (A) The relation between top 20 down/up miRNAs and top 200 up/down DEGs, (B) Model showing that TP-472 treatment activates apoptosis, induces cell cycle arrest, induces miRNA-mediated gene regulation, and reprograms pro-oncogenic epigenome in uLMS cells. Note: Arabic numerals are the index for histone modifications. Figure 9B was created using BioRender software.

Journal: Cells

Article Title: The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma.

doi: 10.3390/cells11142160

Figure Lengend Snippet: Figure 9. Visualization of the top 200 DEGs involved in miRNA regulation. (A) The relation between top 20 down/up miRNAs and top 200 up/down DEGs, (B) Model showing that TP-472 treatment activates apoptosis, induces cell cycle arrest, induces miRNA-mediated gene regulation, and reprograms pro-oncogenic epigenome in uLMS cells. Note: Arabic numerals are the index for histone modifications. Figure 9B was created using BioRender software.

Article Snippet: The leiomyosarcoma (uLMS) cell line (SK-UT1, ATCC® HTB-114TM) (ATCC, Manassas, VA, USA) was cultured and maintained in ATCC-formulated Eagle’s Minimum Essential Medium with 10% of fetal bovine serum.

Techniques: Software